Inferring perturbation profiles of cancer samples
نویسندگان
چکیده
منابع مشابه
Supporting Information to Inferring Regulatory Networks by Combining Perturbation Screens and Steady State Gene Expression Profiles
To show (ii), first assume G is a DAG. In this case, there exists (at least) one causal ordering of its nodes. (Note: all possible orderings in a DAG are valid causal orderings.) However, by the accuracy of the perturbation data assumed, P also forms a DAG. In addition, due to the transitivity of the influence matrix, the ordering of the nodes in the influence matrix is the same as that in G. T...
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Reconstructing transcriptional regulatory networks is an important task in functional genomics. Data obtained from experiments that perturb genes by knockouts or RNA interference contain useful information for addressing this reconstruction problem. However, such data can be limited in size and/or are expensive to acquire. On the other hand, observational data of the organism in steady state (e...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2021
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btab113